NCCN Guideline Compliance — Automated

NCCNCompliance Checker

Prior Auth, Automated

Verify chemotherapy orders against NCCN guidelines in minutes, not hours.
Connect your EHR, upload documents, or receive orders via fax — and get compliance verdicts with alternative regimen suggestions ready for prior authorization.

Fully · Non-Compliant

2 compliance outcomes · 90+ types

Schedule a Demo →◇ Upload a Chemo Order

90+

NCCN cancer types
with dedicated guidelines

Input methods —
EHR, upload, and fax

Minutes

Full extraction and
compliance check

Dual

Independent AI models
cross-validate every extraction

The problem we solve

Why this exists

Manual NCCN compliance verification is slow and error-prone

Prior authorization decisions hinge on guideline compliance. Without automation, every chemo order becomes hours of cross-referencing.

Manual NCCN compliance verification is time-consuming and error-prone:

Payers require NCCN guideline compliance for prior authorization

Clinicians spend hours cross-referencing orders against guidelines

Missed compliance issues delay patient treatment

Alternative regimen identification requires deep guideline knowledge

ClinixBoost automates the entire process.

Input methods

Flexible Input Options

Meet your workflow where it lives

Connect your EHR, upload documents, or receive orders via fax — any combination works. No forced intake format.

◈

EHR Integration

Connect your EHR.

Connect directly to your electronic health record. Pull patient data, active orders, and treatment history automatically — no manual document handling required.

FHIR / HL7 (on roadmap)Direct connection

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Document Upload

Drop chemo orders as PDFs or images.

Upload chemotherapy order sheets as PDFs or images. Multi-page documents are fully supported — AI identifies and extracts orders across all pages.

PDFJPG / PNGMulti-page

✦

Fax-In Processing

Receive orders via eFax.

Receive chemotherapy orders via eFax for automated processing. Ideal for payer workflows and external referrals — zero staff intervention required.

eFaxAutomated intake

How it works

How It Works

From chemo order to compliance report

A fully automated pipeline. No forms. No phone calls. No waiting on hold.

Receive Patient Data

Connect via EHR, upload a chemo order PDF, or receive orders via fax. The system accepts structured EHR data or unstructured clinical documents — no rigid intake format.

EHR · Upload · Fax

Intelligent Page Classification

Not every page is a chemo order. AI classifies each page to identify actual chemotherapy orders, premedications, and signatures — filtering out consent forms, education materials, and irrelevant pages.

Page filtering · Multi-page support

Treatment Extraction

AI extracts structured patient data from your orders: demographics, diagnosis, regimen and medications, dosing (mg/m², mg/kg, AUC), routes, schedules, premedications, cycle information, and hold parameters.

Cross-validated extraction · Structured output

NCCN Guideline Matching

Extracted treatments are matched against current NCCN guidelines. Compliance is determined by matching the patient's clinical scenario to NCCN recommended use — not just evidence category in isolation.

Clinical-indication matching · 90+ cancer types

Compliance Verdict

Each treatment receives a clear determination: Fully Compliant (matches NCCN recommended use for this patient) or Non-Compliant (does not match — requires justification or modification).

Fully Compliant · Non-Compliant

Alternative Regimens

For every case, we identify other NCCN-compliant combination regimens that could serve as alternatives — useful for formulary discussions, payer requirements, or when a treatment switch is needed.

Combination-aware · Formulary-ready

PDF Report & Delivery

Generate a professional compliance report with patient summary, treatment details, compliance status, rationale, NCCN citations, and alternatives. Send via eFax, download, or push back to your EHR.

eFax · Email · EHR push

Key Capabilities

Built for prior authorization at scale

Every capability designed around what payers actually need to approve a treatment on first review.

EHR Integration

EHR Integration on roadmap — FHIR/HL7 connectivity coming soon. Contact us about your EHR.

Multi-Page Order Processing

Handles complex order sets spanning multiple pages with continuation sheets.

Intelligent Page Filtering

Automatically identifies chemo orders vs. consent forms, education materials, and other irrelevant pages.

Cross-Validated Extraction

Two independent AI models cross-validate every extraction for accuracy.

Exact Drug Name Preservation

Keytruda stays Keytruda, not 'pembrolizumab' — extraction matches the clinical documentation as written.

Approved Order Detection

Only processes signed and approved orders; excludes denied, voided, or cancelled orders.

90+ Cancer Types

Coverage across NCCN guideline categories — hematologic, solid tumors, pediatric, and rare cancers.

NCCN Recommended Use Matching

Compliance is determined by clinical indication match — not just evidence category in isolation.

Alternative Regimen Suggestions

Compliant alternatives identified for formulary flexibility and treatment-switch scenarios.

Professional PDF Reports

Branded compliance reports ready for prior authorization submission.

eFax Integration

Send reports directly to payer fax numbers — no manual handoff.

What we extract

Structured Extraction

Everything needed for a defensible compliance report

Patient information, clinical context, treatment details, and order metadata — all extracted automatically from the order.

Patient Information

Name

Date of Birth

Age

Height

Weight

BSA

Allergies

Clinical Context

Primary Diagnosis (ICD)

Cancer Type

Disease Category

Stage

Histology

Biomarker Status

Treatment Details

Regimen Name

Medications

Dosing

Routes

Cycle Day

Frequency

Premedications

Hold Parameters

Order Metadata

Order Date

Ordering Physician

Approval Status

Confidence Scores

Compliance assessment

NCCN Compliance Assessment

Rigorous determination, every time

We match the patient's clinical scenario to NCCN recommended use — not just an evidence category in isolation.

◈

Based on Clinical Indication, Not Just Evidence Level

We match the patient's specific clinical scenario — diagnosis, stage, biomarkers, prior treatments — against the NCCN recommended use text for each agent. Not simply the 1/2A/2B/3 evidence category.

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Combination Regimen Awareness

Modern oncology uses combination regimens. We evaluate the entire treatment combination as a whole — not individual agents in isolation.

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Clear Rationale

Every compliance determination includes detailed rationale: the NCCN guideline section that applies, how the patient's scenario matches recommended use, the evidence category for reporting, and any caveats.

Coverage

90+ Cancer Types

Comprehensive NCCN coverage in one platform

Dedicated NCCN guideline coverage for every major oncology category — hematologic, solid tumors, pediatric, and rare cancers.

AML

B-Cell Lymphoma

T-Cell Lymphoma

CLL / CML

Hodgkin

Myeloma

MDS / MPN

Waldenström's

NSCLC / SCLC

Breast

Prostate

Colon / Rectal

Pancreatic

HCC

Melanoma

Ovarian

Cervical

Head & Neck

Bladder

CNS Tumors

Sarcoma / GIST

Thyroid

Esophageal

Gastric

Renal Cell

Endometrial

Pediatric ALL

Wilms Tumor

Neuroblastoma

Neuroendocrine

+ 60 more

Compliance Outcomes

Two clear verdicts. Every one defended with citations.

Each treatment receives a clear determination — Fully Compliant or Non-Compliant — with NCCN section citations, evidence categories, and alternative regimens for context.

Fully Compliant

Treatment matches NCCN recommended use for the patient's clinical scenario — diagnosis, stage, biomarkers, and treatment line.

Non-Compliant

Treatment does not match NCCN recommended use — requires justification or modification. Alternative compliant regimens are surfaced in the report.

Professional reports

Professional Reports

Compliance reports ready for payer submission

Branded PDF reports include patient summary, treatment details, compliance status, citations, and alternatives — formatted for professional presentation.

Reports are formatted for professional presentation to payers, tumor boards, or medical records.

Header

Patient demographics, report date, and case reference identifiers.

Diagnosis Section

Cancer type, disease category, stage, and biomarker status.

Current Treatment

Extracted regimen with all medications, dosing, routes, and schedules.

Compliance Assessment

Per-agent and overall compliance status with detailed rationale.

NCCN Reference

Guideline name, recommended use text, and evidence category.

Alternative Regimens

Other compliant options for this patient scenario.

Audit Trail

Confidence scores and source references for every extraction.

Disclaimer

Appropriate clinical and legal language for payer review.

See it in action

Real Example

From clinical note to compliance report

Here's a sample patient's clinical note alongside the NCCN compliance report ClinixBoost generates from it. Click either card to view the full PDF.

Before

Clinical Note

Raw clinical documentation as received

View Full PDF→

After

NCCN Compliance Report

AI-generated compliance verdict with citations

View Full PDF→

Example uses a fictional patient; all PHI has been removed.

Integration & workflow

Integration & Workflow

Designed to plug into your existing process

Whether you live in your EHR or run prior auth review by fax, the Compliance Checker meets you there.

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EHR-Native Workflows

Embed compliance checking directly in your oncology workflow. Pull orders from your EHR, return compliance status and reports without leaving your system.

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Fax-In, Fax-Out

Receive chemo orders via eFax, process automatically, return the compliance report via eFax — seamless integration with existing payer workflows.

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Prior Authorization Ready

Reports are designed to meet payer documentation requirements for oncology prior authorization — ready for submission as generated.

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Audit Trail

All extractions include confidence scores and source references for auditability — defensible end-to-end.

Who It's For

Four audiences. One compliance platform.

Whether you generate prior auths, review them, or dispense the resulting treatment — the Compliance Checker fits.

Oncology Practices

Streamline prior authorization documentation. Reduce administrative burden on clinical staff. Integrate with your existing EHR.

Health Plans & PBMs

Automate medical necessity review for oncology. Consistent, guideline-based determinations at scale.

Hospital Pharmacy

Verify protocol compliance before dispensing. Identify when clinical consultation is needed.

Oncology Clinical Reviewers

Accelerate case review with pre-extracted data and automated guideline matching.

Get started

Prior authorization doesn't have to take days anymore.

For oncology practices, IPAs, and health plans ready to replace manual compliance review with defensible AI-generated reports.

Schedule a Demo →◇ Contact Us for Enterprise Deployment

◈ NCCN Grounded✦ 90+ Cancer Types○ EHR-Ready◇ Fax-In Fax-Out⬡ Audit Trail